关注孕期可乐对ART妇女的影响，预防ART治疗期间不利的出生结局

The associations of cola intake with adverse birth outcomes among pregnant women after assisted reproductive technology treatment and women naturally conceived: a birth cohort study

辅助生殖技术治疗后孕妇和自然受孕孕妇的可乐摄入量与不良出生结局的关联：一项出生队列研究

Authors：Shen C, Hou R, Zhang X, Cai G, Liang C, Gan H, Xu X, Xiang H, Tao F, Cao Y, Peng X.

Source：Hum Fertil (Camb) . 2023 Dec;26(6):1503-1510.

Doi: 10.1080/14647273.2023.2286347

Abstract

Background:The consumption of cola is one of the largest sales worldwide , but the potential detrimental effect of cola on birth outcomes tends to be neglected compared with alcohol and coffee.

Objective:The influence of cola intake on birth outcomes is unclear. This study sought to describe and compare the associations between cola intake and adverse birth outcomes among women following assisted reproductive technology (ART) and women spontaneously conceived (SC).

Methods:Participants (736 ART women and 1,270 SC women) were from the Chinese National Birth Cohort collected in Anhui province. Cola intake was assessed by self-reported questionnaires at each trimester. Outcome measures including preterm birth (PTB) and low birth weight (LBW) were extracted from medical records. The association between cola intake during pregnancy and PTB was found using multivariable log-binomial regression in combined ART and SC women.

Results: for ART women, cola intake during pregnancy increased the risk of PTB (risk ratios were 2.10, 1.65, and 1.81 for all three trimesters, respectively, all p < 0.05), and cola intake in the 1st trimester increased the risk of LWB (risk ratio 2.58, 95% confidence interval 1.29 to 5.16). Cola intake during pregnancy was not associated with PTB or LBW for SC women.

Conclusions:Our findings indicate a detrimental effect of cola intake during pregnancy on birth outcomes for ART women. Thus, avoidance of cola intake should be counselled by medical doctors in women prescribed with ART treatment.

Keywords: Drinking behaviour; assisted reproductive technology; beverages; food intake

摘要

背景：可乐是全球最畅销的饮品之一，然而相较于酒和咖啡，其对出生结局的潜在破坏性影响往往被忽视。

目的：可乐摄入量对出生结局的影响尚不清楚。本研究旨在描述并比较饮用可乐与辅助生殖技术(ART)和自然受孕(SC)妇女不良出生结局之间的关联。

方法：研究对象来自中国国家出生队列在安徽省收集的736名ART妇女和1270名SC妇女。每三个月通过自我报告的问卷评估可乐摄入量。结局指标包括早产(PTB)和低出生体重(LBW)。采用多变量log-binomial回归分析ART和SC妇女妊娠期可乐摄入量与PTB的关系。

结果：对于ART妇女，妊娠期饮用可乐增加了PTB的风险(在所有妊娠的早中晚期的风险比分别为2.10，1.65和1.81，均p < 0.05）;孕早期饮用可乐可增加LWB的发生风险(风险比2.58，95%可信区间1.29 -5.16)。在SC妇女中，妊娠期可乐摄入量与PTB或LBW无关。

结论：我们的研究结果表明，孕期可乐摄入对ART妇女的出生结局有不利影响。因此，医生应该建议接受ART治疗的女性避免饮用可乐。