母亲怀孕期间暴露于全氟和多氟烷基物质，可能会导致胎盘重量的增加以及胎盘效率的降低

Impact of Gestational Exposure to Individual and Combined Per- and Polyfluoroalkyl Substances on a Placental Structure and Efficiency: Findings from the Ma’anshan Birth Cohort

妊娠期单独和混合暴露于全氟和多氟烷基物质对胎盘结构和效率的影响:来自马鞍山优生优育队列的研究结果

Author: Hong Gan, Yanan Xing, Juan Tong, Mengjuan Lu, Shuangqin Yan, Kun Huang, Xiaoyan Wu, Shuman Tao, Hui Gao, Yitao Pan, Jiayin Dai, Fangbiao Tao

Source: Environmental Science & Technology

DOI: 10.1021/acs.est.3c09611.

Abstract

Prenatal exposure to per- and polyfluoroalkyl substances (PFAS) is inevitable among pregnant women. Nevertheless, there is a scarcity of research investigating the connections between prenatal PFAS exposure and placental structure and efficiency. Based on 712 maternal-fetal dyads in the Ma’anshan Birth Cohort, we analyzed associations between individual and mixed PFAS exposure and placental measures. We repeatedly measured 12 PFAS in maternal serum during pregnancy. Placental weight, scaling exponent, chorionic disc area, and disc eccentricity were used as outcome variables. Upon adjusting for confounders and implementing corrections for multiple comparisons, we identified positive associations between branched perfluorohexane sulfonate (br-PFHxS) and 6:2 chlorinated polyfluorinated ether sulfonate (6:2 Cl-PFESA) with placental weight. Additionally, a positive association was observed between br-PFHxS and the scaling exponent, where a higher scaling exponent signified reduced placental efficiency. Based on neonatal sex stratification, female infants were found to be more susceptible to the adverse effects of PFAS exposure. Mixed exposure modeling revealed that mixed PFAS exposure was positively associated with placental weight and the scaling exponent, particularly during the second and third trimesters. Furthermore, br-PFHxS and 6:2 Cl-PFESA played major roles in placental measures. This study provides the first epidemiological evidence of the relationship between prenatal PFAS exposure and placental measures.

Keywords: PFAS; Placental efficiency; Quantile g-computation; Bayesian kernel machine regression; Multivariate generalization propensity score; Birth cohort.

摘要

孕妇产前接触全氟和多氟烷基物质（perfluoroalkyl and polyfluoroalkyl substances, PFASs）是不可避免的。然而，关于产前PFAS暴露与胎盘结构和效率之间关联的研究罕见。基于马鞍山优生优育队列的712对母子对，我们分析了12种PFAS单独以及混合暴露与胎盘测量之间的关系。我们在妊娠期间重复检测了母体血清中的12种PFASs。以胎盘重量、缩放指数（与胎盘效率呈反比）、绒毛膜面积、胎盘偏心率作为结局变量。在调整混杂因素并进行多重假设检验校正后，我们发现支链全氟己烷磺酸（br-PFHxS）和6:2氯化多氟醚磺酸（6:2 Cl-PFESA）与胎盘重量呈正相关。此外，br-PFHxS与缩放指数呈正相关，缩放指数越高，胎盘效率越低。根据新生儿性别分层，发现女婴更容易受到PFAS暴露的不良影响。混合暴露模型显示，PFAS混合暴露与胎盘重量和缩放指数呈正相关，特别是在妊娠中晚期。br-PFHxS和6:2 Cl-PFESA在胎盘结构和效率中起主要作用。这项研究是孕母产前PFAS暴露与胎盘结构和效率之间流行病学关联的首次探索。