早期青少年外周血炎症指标的升高与随后抑郁的发生风险的增加可能存在性别差异

Sex-specific association of peripheral blood cell indices and inflammatory markers with depressive symptoms in early adolescence

外周血细胞指数和炎症标志物与早期青少年抑郁症状的性别特异性关联

Authors：Wen X, Wang F, Tang T, Xu B, Yuan M, Li Y, Ding H, Tao F, Su P, Wang G.

Source: J Affect Disord.

 DOI: 10.1016/j.jad.2024.06.098.

Abstract: 

Background: Previous studies have reported the correlation of dysregulated blood cell indices and peripheral inflammatory markers with depression in adults but limited studies have examined this correlation in early adolescents.

Methods: This study used data from the Chinese Early Adolescents Cohort Study, which was conducted in Anhui, China. Students' depression symptoms were repeatedly measured using the Chinese version of the Center for Epidemiological Studies Depression Scale for Children. Students' blood samples were collected in September 2019 and September 2021. The peripheral blood cell counts and inflammatory marker levels were determined using routine blood tests. Multivariable regression models were used to explore the associations between blood cell indices and adolescent depressive symptoms in both the whole sample and the sex-stratified samples.

Results: The white blood cell (WBC) count, neutrophil count (NC), platelet (PLT) count, neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio, and systemic immune inflammation index (SII) were positively correlated with the severity of depressive symptoms during follow-up. The mean corpuscular volume (MCV), mean hemoglobin (HGB) volume (MCH), and mean corpuscular HGB concentration (MCHC) exhibited negative temporal correlations with depressive symptoms. Additionally, several sex-specific blood cell markers were correlated with depression. Male adolescents with increased red blood cell (RBC) and female adolescents with decreased HGB levels and upregulated WBC, NC, NLR, and SII levels exhibited severe depressive symptoms at follow-up.

Conclusions: These findings suggested the potential usefulness of peripheral blood cell indices in the assessment of depression in early adolescents.

摘要：

背景：以往的研究报道了成人中异常的血细胞指数和外周炎症标志物与抑郁症的关联，但很少有研究在早期青少年中分析两者之间的关联。

方法：本研究使用的数据来自一项中国早期青少年队列研究，该研究在中国安徽进行。使用中文版的流行病学研究中心儿童抑郁量表测量学生的抑郁症状。分别于2019年9月和2021年9月采集学生血样。外周血细胞计数和炎症标志物水平采用常规血液检查。利用多变量回归模型探讨全人群以及性别分层样本中血细胞指数与青少年抑郁症状之间的关系。

结果：白细胞（WBC）计数、中性粒细胞计数（NC）、血小板计数（PLT）、中性粒细胞与淋巴细胞比值（NLR）、血小板与淋巴细胞比值、全身免疫炎症指数（SII）在随访期间的变化与抑郁症状严重程度呈正相关。平均红细胞体积（MCV）、平均血红蛋白体积（MCH）和平均红细胞血红蛋白浓度（MCHC）与抑郁症状在时间变化上呈负相关。此外，一些血细胞指标与抑郁症状的关联存在性别特异性。在随访期间，红细胞（RBC）增加的男性青少年和HGB水平降低、WBC、NC、NLR和SII水平升高的女性青少年表现出更严重的抑郁症状。

结论：本研究提示外周血细胞指数在早期青少年抑郁症状评估中的潜在作用。