Ceramide as a Promising Tool for Diagnosis and Treatment of Clinical Diseases: A Review of Recent Advances

神经酰胺是诊断和治疗临床疾病的有效工具：最新进展综述

Authors：Xueping Shen, Rui Feng, Rui Zhou, Zhaoyang Zhang, Kaiyong Liu, Sheng Wang

Source：Metabolites

DOI: 10.3390/metabo15030195

Abstract

Background/Objectives: Ceramide, a sphingolipid metabolite, has emerged as a key player in various physiological and pathological processes. Changes in ceramide levels are associated with the occurrence and development of various diseases, highlighting its potential as a biomarker of various clinical diseases.

Methods: The biosynthesis and metabolism of ceramide are discussed, along with its functions in cell signaling, apoptosis, and inflammation. This study further examines the potential of ceramide as a biomarker for disease diagnosis and treatment.

Results: This article highlights the involvement of ceramide in several diseases, including cardiovascular diseases, dermatosis, cancer, neurodegenerative disorders and metabolic syndromes. For each disease, the potential of ceramide as a biomarker for disease diagnosis and prognosis is explored, and the feasibility of therapeutic strategies targeting ceramide metabolism are reviewed. Additionally, the challenges and future directions in the field of ceramide research are addressed.

Conclusions: This review article provides an overview of the recent advances in understanding the role of ceramide in clinical diseases and its potential as a diagnostic and therapeutic tool.

Keywords: Alzheimer’s disease; cancer; cardiovascular disease; ceramides; dermatosis; obesity

摘要：

背景/目的：神经酰胺是一种鞘脂代谢物，在各种生理和病理过程中起着关键作用。神经酰胺水平的变化与各种疾病的发生和发展有关，这凸显了神经酰胺作为各种临床疾病生物标志物的潜力。

研究方法：本研究讨论了神经酰胺的生物合成和代谢及其在细胞信号传导、细胞凋亡和炎症中的功能。本研究进一步探讨了神经酰胺作为疾病诊断和治疗生物标志物的潜力。

研究结果：本文重点介绍了神经酰胺与多种疾病的关系，包括心血管疾病、皮肤病、癌症、神经退行性疾病和代谢综合征。针对每种疾病，文章探讨了神经酰胺作为疾病诊断和预后生物标志物的潜力，并综述了针对神经酰胺代谢的治疗策略的可行性。此外，还探讨了神经酰胺研究领域的挑战和未来方向。

结论：这篇综述文章概述了人们在了解神经酰胺在临床疾病中的作用及其作为诊断和治疗工具的潜力方面取得的最新进展。

关键词： 阿尔茨海默病；癌症；心血管疾病；神经酰胺；皮肤病；肥胖