母亲妊娠期轻度贫血可能以性别特异性方式影响儿童行为发育

Sex-specific Association between Maternal Mild Anemia and Children's Behavioral Development: A Birth Cohort Study

母亲轻度贫血与儿童行为发育之间的性别特异性关联：一项出生队列研究

Author: Xuemei Hao, Yufan Guo, Jingru Lu, Linlin Zhu, Shuangqin Yan, Fangbiao Tao, Kun Huang

Source: European Child & Adolescent Psychiatry

DOI: 10.1007/s00787-024-02411-z

Abstract

There has been limited research on maternal anemia affecting children's behavioral development, with a lack of studies focusing on sex differences in this association. Based on the Ma'anshan Birth Cohort, 2132 mother-child pairs were included. Maternal anemia was evaluated based on the hemoglobin concentration and children's behavioral development was assessed by Achenbach Child Behavior Checklist 1.5-5. Binary logistic regression models indicated that compared with children born of mothers without anemia throughout pregnancy, maternal mild anemia during pregnancy or only anemia in the 3rd trimester was associated with increased risks of aggressive behaviors in boys. Maternal mild anemia only in the 2nd trimester was associated with increased risks of attention problems in boys. In girls, maternal mild anemia during pregnancy was associated with increased risks of withdrawn, internalizing problems and total problems. Girls born of mothers with mild anemia only in the 2nd trimester had higher risks of total problems. Maternal mild anemia in both 2nd and 3rd trimesters was associated with increased risks of internalizing problems in girls. Our study identified sex-specific effects of maternal mild anemia during pregnancy on children's behavioral development problems.

Keywords: Behavioral development; Children; Cohort study; Maternal; Mild anemia

摘要：

目前关于母亲妊娠期贫血影响儿童行为发育的研究较少，且缺乏关于这一关联的性别特异性研究。本研究基于马鞍山优生优育队列（MABC），共纳入2132对母子。根据血红蛋白浓度评估母亲贫血状况，采用Achenbach儿童行为检查表（CBCL/1.5-5）评估儿童的行为发育问题。二元logistic回归模型显示，与整个妊娠期间都没有贫血的母亲所生的孩子相比，母亲妊娠期有轻度贫血或仅妊娠晚期轻度贫血与男童的攻击性行为风险增加有关。母亲仅在妊娠中期轻度贫血与男童的注意问题风险增加有关。母亲妊娠期有轻度贫血与女童退缩、内化问题和总行为问题的风险增加有关。母亲仅在妊娠中期轻度贫血与女童的总行为问题风险增加有关。母亲在妊娠中期和晚期均轻度贫血与女童的内化问题风险增加有关。我们的研究表明了母亲妊娠期轻度贫血对儿童行为发育问题的性别特异性影响。

关键词：行为发育；儿童；队列研究；母亲；轻度贫血