高水平的膳食支链氨基酸摄入和循环支链氨基酸浓度可能会促进体脂的积累

Dietary and circulating BCAAs are unfavorably associated with body fat measures among Chinese adults

膳食和循环支链氨基酸与中国成年人的体脂测量呈不利影响

Author: Yaozong Zhang, Songxian Rao, Xiaoyu Zhang, Zhaohong Peng, Wen Song, Shaoyu Xie, Hongjuan Cao, Zhuang Zhang, Wanshui Yang

Source: Nutrition Research

DOI: 10.1016/j.nutres.2024.06.009

Abstract

Animal studies showed a detrimental effect of dietary branched chain amino acids (BCAAs) on metabolic health, while epidemiological evidence on dietary BCAAs and obesity is limited and inconclusive. We hypothesized that high dietary and circulating BCAAs are unfavorably associated with obesity in community-dwelling adults. We evaluated the 1-year longitudinal associations of dietary BCAA intake and circulating BCAAs with body fat measures. Body weight, height, and circumferences of the waist (WC) and hip (HC) were measured at baseline and again after 1-year. Body composition and liver fat [indicated by controlled attenuation parameter (CAP)] were also assessed after 1-year. Serum BCAA concentrations at baseline was quantified by liquid chromatography mass spectrometry. Diet was collected using 4 quarterly 3-day recalls during the 1-year. The correlation coefficients between dietary and serum BCAAs were 0.12 (P=0.035) for total dietary BCAAs, and ranged from -0.02 (soy foods, P=0.749) to 0.18 (poultry, P=0.001). Total dietary BCAA intake was associated with increase in body weight (β=0.044, P=0.022) and body mass index (BMI, β=0.047, P=0.043). BCAAs from animal foods were associated with increase in HC, while BCAAs from soy foods were associated with weight gain and higher CAP (all P<0.05). Serum BCAAs were associated with higher WC, HC, BMI, body fat mass, visceral fat level, and CAP (all P<0.05). These results support that dietary and circulating BCAAs are positively associated with the risk of obesity. More cohort studies with validated dietary assessment tools and long-term follow-up among diverse populations are needed to confirm our findings.

摘要

动物实验表明，膳食支链氨基酸（BCAAs）对代谢健康存在不利影响，而关于膳食BCAAs与肥胖的流行病学证据有限且结论并不一致。我们假设高水平的膳食和循环BCAAs与社区成年人的肥胖存在不利关联。我们评估了膳食BCAAs摄入和循环BCAAs浓度与体脂测量之间的1年期纵向关联。体重、身高、腰围（WC）和臀围（HC）分别在基线时和一年后随访时进行了测量。在1年后的随访中还对身体成分和肝脏脂肪（用受控衰减参数（CAP）表示）进行了评估。基线时的血清BCAAs浓度是通过液相色谱串联质谱法进行检测。在1年的随访期间，通过4个季度的3天24小时膳食回顾收集了饮食信息。总膳食BCAAs和血清BCAAs之间的相关系数为0.12（P=0.035），相关系数范围为-0.02（豆类食物，P=0.749）至0.18（家禽，P=0.001）。总膳食BCAAs的摄入与体重（β=0.044，P=0.022）和体质指数（BMI，β=0.047，P=0.043）的增加有关。动物性食物来源的BCAAs与HC的增加有关，而豆类食物来源的BCAAs与体重增加和更高的CAP有关（所有P<0.05）。血清中的BCAAs与较高的WC、HC、BMI、体脂量、内脏脂肪水平和CAP相关（所有P<0.05）。这些结果支持了膳食和循环BCAAs与肥胖风险呈正相关。要证实我们的研究结果，还需要在不同人群中使用经过验证的膳食评估工具去进行更多长期的随访和队列研究。