双酚类物质和全氟及多氟烷基物质暴露与我国学龄前儿童行为问题之间的关联

Association between exposure to bisphenols and per- and polyfluoroalkyl substances and behavioral problems among Chinese preschoolers

双酚类物质和全氟及多氟烷基物质暴露与我国学龄前儿童行为问题之间的关联

Authors: Ruo-Yu Li, Jun Wu, Wan Xiao, Yang Zhou, Ke Liang, Jia-Ying Bao, Zhi-Yuan Yao, Chao Zhang, Yu-Hui Wan

Source：Ecotoxicology And Environmental Safety

DOI: 10.1016/j.ecoenv.2025.118548

Abstract

In order to fill the gap in previous research, we aim to investigate the relationship between single and co-exposure to bisphenols (BPs) and per- and polyfluoroalkyl substances (PFAS) and behavioral problems among Chinese preschoolers. The current study measured urinary BPs and PFAS concentrations in 823 Chinese preschoolers. The children's behavioral problems were assessed using the Conners' Parent Symptom Questionnaire (PSQ). Binary logistic regression, weighted quantile sum (WQS) regression, and Bayesian kernel machine regression (BKMR) were used to examine the association between single or co-exposure to all chemicals and behavioral problems among preschoolers. After controlling for covariates, binary logistic regression results showed that bisphenol AP (BPAP), bisphenol B (BPB), bisphenol S (BPS), perfluorobutanesulfonic acid (PFBS), perfluorohexanesulfonic acid (PFHxS), and perfluorooctane sulphonate (PFOS) were significantly associated with children's behavioral problems (OR = 1.89-2.60, 95 % CI: 1.01-5.21). The WQS index was significantly positively associated with behavioral problems (OR = 2.01, 95 % CI: 1.24-3.32). BPAP and PFHxS were the chemicals with the most significant weights. BKMR results also found that the mixture of BPs and PFAS had a partially significant positive association with preschoolers' behavioral problems. This study indicated that a mixture of urinary BPs and PFAS has a combined effect on behavioral problems in preschoolers. In addition, BPAP and PFHxS, which are common substitutes for BPA and PFOS respectively, have a greater impact on preschoolers' behavioral problems and are worthy of further attention.

Keywords: Behavioral problems; Bisphenols; Per- and polyfluoroalkyl substances; Preschoolers.

摘要

为了弥补先前研究中的空白，我们旨在探讨双酚类物质（BPs）和全氟烷基及多氟烷基物质（PFAS）的单一暴露与联合暴露与中国学龄前儿童行为问题之间的关系。本研究测量了823名中国学龄前儿童尿液中BPs和PFAS的浓度。儿童的行为问题通过康纳斯父母症状问卷（PSQ）进行评估。采用二元逻辑回归、加权分位数和（WQS）回归以及贝叶斯核机器回归（BKMR）方法，分析了单一或联合暴露于所有化学物质与学龄前儿童行为问题之间的关联。在控制协变量后，二元逻辑回归结果显示，双酚A-P（BPAP）、双酚B（BPB）、双酚S （BPS）、全氟丁磺酸（PFBS）、全氟己磺酸（PFHxS）和全氟辛磺酸（PFOS）与儿童行为问题显著相关（OR = 1.89-2.60，95% CI：1.01-5.21）。WQS指数与行为问题显著正相关（OR = 2.01，95% CI：1.24-3.32）。BPAP和PFHxS是权重最大的化学物质。BKMR结果还发现，双酚类和全氟烷基物质的混合物与学龄前儿童的行为问题存在部分显著正相关。本研究表明，尿液中双酚类和全氟烷基物质的混合物对学龄前儿童的行为问题具有综合影响。此外，作为双酚A和全氟辛烷磺酸的常见替代品，双酚A和全氟辛烷磺酸对学龄前儿童的行为问题影响更大，值得进一步关注。

关键词：行为问题；双酚类；全氟烷基物质；学龄前儿童。