Real-ambient bedroom light at night increases systemic inflammation and disrupts circadian rhythm of inflammatory markers
真实环境卧室夜间光增加系统炎症并破坏炎症标志物的昼夜节律
Authors: Yu-xiang Xu, Yu-ting Shen, Jing Li, Wen-qin Ding, Yu-hui Wan, Pu-yu Su, Fang-biao Tao, Ying Sun
Source: Ecotoxicol Environ Saf. 2024 Jun 20; 281: 116590.
DOI: 10.1016/j.ecoenv.2024.116590.
Graphical Abstract
Abstract
Background: Exposure to light at night (LAN) has been associated with multiple adverse health outcomes. However, evidence is limited regarding the impacts of LAN exposure on human inflammation.
Objectives: To examine the association between real-ambient bedroom LAN exposure with systemic inflammation and circadian rhythm of inflammatory markers.
Methods: Using data from a prospective cohort study of Chinese young adults. At baseline, bedroom LAN exposure was measured with a portable illuminance meter; fasting blood sample for high-sensitivity C-reactive protein (hs-CRP) assay was collected. At 3-year follow-up, 20 healthy young adults (10 LANavg < 5lx, 10 LANavg ≥ 5lx) were recruited from the same cohort; time-series venous blood samples were sampled every 4 h over a 24 h-cycle for the detection of 8 inflammatory markers. Circadian rhythm of inflammatory markers was assessed using cosinor analysis.
Results: At baseline, the average age of the 276 participants was 18.7 years, and 33.3% were male. Higher levels of bedroom LAN exposure were significantly associated with increased hs-CRP levels. The association between bedroom LAN exposure and systemic inflammation was only significant in the inactive group (MVPA < 2 h/d) but not in the physically active group (MVPA ≥ 2h/d). In addition, exposure to higher levels of nighttime light (LANavg ≥ 5lx) disrupted circadian rhythms (including rhythmic expression, circadian amplitude and circadian phase) of some inflammatory cytokines and inflammatory balance indicators.
Conclusions: Exposure to bedroom nighttime light increases systemic inflammation and disrupts circadian rhythm of inflammatory markers. Keep bedroom darkness at night may represent important strategies for the prevention of chronic inflammation. Additionally, for people living a community with higher nighttime light pollution, regular physical activity may be a viable option to counteract the negative impacts of LAN exposure on chronic inflammation.
摘要
背景:夜间光暴露(light at night,LAN)与多种不良健康结局相关。然而,LAN暴露对人类炎症影响的证据较少。
目的:本研究的目的是探索真实环境卧室LAN暴露与系统炎症及炎症标志物昼夜节律的关联。
方法:数据来自一项在中国青年中开展的前瞻性队列。基线时,使用便携式照度计测量卧室LAN暴露,并收集空腹静脉血以检测hs-CRP。在3年随访调查时,招募该队列中20名受试者(10名LANavg < 5lx,10名LANavg ≥ 5lx),在24小时内每4小时采集一次静脉血,采集的血样检测8种炎症标志物。基于余弦分析(cosinor analysis)拟合炎症生物标志物的昼夜节律。
结果:基线时,276名受试者的平均年龄为18.7岁,33.3%为男性。较高水平的卧室LAN暴露与hs-CRP水平增加显著相关。LAN暴露与系统炎症的关联仅在体力活动相对较低组(MVPA < 2 h/d)中显著,而在体力活动较高组(MVPA ≥ 2h/d)中关联没有统计学意义。此外,暴露于较高水平的LAN暴露(LANavg ≥ 5lx)破坏了部分炎症细胞因子和炎症平衡指标的昼夜节律(包括昼夜节律性、振幅和时相)。
结论:卧室LAN暴露增加系统炎症并破坏炎症标志物的昼夜节律。保持卧室夜间黑暗可能是预防慢性炎症的一个重要策略。此外,对于居住在夜间光污染较高地区的个体,定期的体力活动可能是缓解LAN暴露对慢性炎症不良影响的一种可行措施。
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