Associations of toxic metals and their mixture with hyperuricemia in Chinese rural older adults
有毒金属及其混合物与中国农村老年人高尿酸血症的关联
Author: Hongli Wang, Yan Zhang, Liang Sun, Xianwei Guo, Qiang Liu, Junzhe Li, Ziwei Tian, Xuqiu Cheng, Yuan Wang, Huaibiao Li, Bing Hu, Jie Sheng, Guangbo Qu, Guimei Chen, Xuechun Liu, Wenbo Lin, Fangbiao Tao, Linsheng Yang
Source: Environmental Geochemistry and Health
DOI: 10.1007/s10653-024-02035-x.
Abstract
Previous studies have related single toxic metals (TMs) to hyperuricemia (HUA) among the general population, however, the association of the TM mixture with HUA, especially in older adults, remains poorly understood. We aimed to examine the relationships between individual TMs and their mixture and HUA in Chinese rural older adults. This study consisted of 2075 rural older adults aged 60 years or over. Blood concentrations of aluminum (Al), arsenic (As), barium (Ba), cadmium (Cd), cesium (Cs), gallium (Ga), mercury (Hg), lead (Pb), thallium (Tl), and uranium (U) were detected using inductively coupled plasma mass spectrometry. The associations of single TMs with HUA were assessed using logistic regression and restricted cubic spline (RCS) models, and the association of TM mixture with HUA was explored using the elastic net with environmental risk score (ENET-ERS), quantile g-computation (QGC), and Bayesian kernel machine regression (BKMR) models, respectively. Adjusted logistic regression model showed that Cs (OR = 1.65, 95% CI, 1.37-1.99) and Pb (OR = 1.46, 95% CI, 1.28-1.67) were positively related to HUA, and RCS model exhibited a positive linear association of Cs and Pb with HUA. ENET-ERS and QGC models quantified a positive correlation between the TM mixture and the odds of HUA, with estimated ORs of 1.15 (95% CI, 1.11-1.19) and 1.84 (95% CI, 1.37-2.47), respectively, and Cs and Pb had the most weight. BKMR model demonstrated a significant linear association between the TM mixture and increased odds of HUA, with the posterior inclusion probabilities (PIPs) of both Cs and Pb being 1.00. Moreover, we observed a positive interaction between Cs and Pb on HUA. The TM mixture is associated with increased odds of HUA in rural older adults, which may mainly be driven by Cs and Pb. Subsequent studies are warranted to confirm these findings and clarify the mechanisms linking multiple TMs with HUA.
Keywords: Toxic metals; Hyperuricemia; Rural older adults; BKMR; ENET-ERS; QGC.
摘要
先前的研究表明,在普通人群中,个别有毒金属(TM)与高尿酸血症(HUA)有关,但TM混合物与HUA的关联,尤其是在老年人中,仍知之甚少。我们旨在调查中国农村老年人个体TMs及其混合物与HUA的关联。这项研究包括2075名60岁及以上的农村老年人。通过电感耦合等离子体质谱仪检测血液中铝(Al)、砷(As)、钡(Ba)、镉(Cd)、铯(Cs)、镓(Ga)、汞(Hg)、铅(Pb)、铊(Tl)和铀(U)的浓度。使用logistic回归和限制性三次样条(RCS)模型评估单个TM与HUA的关联,并分别使用弹性网络-环境风险评分(ENET-ERS)、分位数g计算(QGC)和贝叶斯核机器回归(BKMR)模型研究TM混合物与HUA之间的关联。校正后的logistic回归模型显示Cs(OR=1.65,95%CI, 1.37-1.99)和Pb(OR=1.46,95%CI, 1.28-1.67)与HUA呈正相关,RCS模型也显示Cs和Pb与HUA呈正线性相关。ENET-ERS和QGC模型量化了TM混合物与HUA几率之间的正相关,OR值分别为1.15(95%CI,1.11-1.19)和1.84(95%CI,1.37-2.47),其中Cs和Pb的重量最大。BKMR模型显示TM混合物与HUA患病几率增加之间存在显著的线性相关性,Cs和Pb的后验包含概率(PIP)均为1.00。我们还观察到Cs和Pb与在HUA之间存在显著的正交互作用。TM混合物与农村老年人发生HUA的几率增加有关,这可能主要由Cs和Pb引起。需要进一步的研究来证实这些发现,并阐明多个TM与HUA之间的关联机制。
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