Urinary enterolignans and enterolignan-predicting microbial species are favourably associated with liver fat and other obesity markers
尿液肠木脂素及肠木脂素代谢相关肠道菌群与肝脏脂肪和其他肥胖指标的改善相关
Author: Yufeng Mo, Yamin Li, Shaoxian Liang, Wuqi Wang, Honghua Zhang, Jiajia Zhao, Mengting Xu, Xiaoyu Zhang, Hongjuan Cao, Shaoyu Xie, Yaning Lv, Yaqin Wu, Zhuang Zhang, Wanshui Yang
Source: Food & Function
DOI: 10.1039/d3fo05632e
Abstract
Aims: Plant-derived lignans may protect against obesity, while their bioactivity needs gut microbial conversion to enterolignans. We used repeated measures to identify enterolignan-predicting microbial species and investigate whether enterolignans and enterolignan-predicting microbial species are associated with obesity. Methods: Urinary enterolignans, fecal microbiota, body weight, height, and circumferences of the waist (WC) and hips (HC) were repeatedly measured at the baseline and after 1 year in 305 community-dwelling adults in Huoshan, China. Body composition and liver fat [indicated by the controlled attenuation parameter (CAP)] were measured after 1 year. Multivariate-adjusted linear models and linear mixed-effects models were used to analyze single and repeated measurements, respectively. Results: Enterolactone and enterodiol levels were both inversely associated with the waist-to-hip ratio, body fat mass (BFM), visceral fat level (VFL), and liver fat accumulation (all P<0.05). Enterolactone levels were also associated with lower WC (β=−0.0035 and P= 0.013) and HC (β=−0.0028 and P=0.044). We identified multiple bacterial genera whose relative abundance was positively associated with the levels of enterolactone (26 genera) and enterodiol (22 genera, all P false discovery rate <0.05), and constructed the enterolactone-predicting microbial score and enterodiol-predicting microbial score to reflect the overall enterolignan-producing potential of the host gut microbiota. Both these scores were associated with lower body weight and CAP (all P<0.05). The enterolactone-predicting microbial score was also inversely associated with the BFM (β=−0.1128 and P=0.027) and VFL (β=−0.1265 and P=0.044). Conclusion: Our findings support that modulating the host gut microbiome could be a potential strategy to prevent obesity by enhancing the production of enterolignans.
摘要
目的:植物性木脂素可能对肥胖有预防作用,但其生物学活性的发挥必须依赖肠道菌群代谢形成肠木脂素。我们使用了重复测量方法来鉴定肠木脂素生成相关肠道菌群,并研究肠木脂素和肠木脂素生成相关肠道菌群与肥胖的关系。方法:在中国霍山的305名社区居民中,分别在基线和随访1年后重复测量尿液肠木脂素、粪便微生物群、体重、身高、腰围(circumferences of the waist,WC)和臀围(circumferences of the hips,HC)。在随访1年后测量体成分和肝脏脂肪[以控制衰减参数(controlled attenuation parameter,CAP)表示]。采用多变量调整线性模型和线性混合效应模型分别分析单次和重复测量的数据。结果:肠内酯和肠二醇水平与腰臀比、体脂质量(body fat mass,BFM)、内脏脂肪水平(visceral fat level,VFL)和肝脏脂肪堆积呈负相关(所有P值均<0.05)。肠内酯水平也与较低的WC(β=−0.0035,P=0.013)和HC(β=−0.0028,P=0.044)相关。我们鉴定了多个肠道微生物菌属,其相对丰度与肠内酯(26种属)和肠二醇(22种属)的水平呈正相关(经错误发现率校正后P均<0.05,),并构建了肠内酯代谢相关肠道菌群评分和肠二醇代谢相关肠道菌群评分,以反映宿主肠道微生物群的肠木脂素整体生产潜力。这两项评分均与较低体重和CAP相关(所有P均<0.05)。肠内酯代谢相关肠道菌群评分与BFM(β=−0.1128,P=0.027)和VFL(β=−0.1265,P=0.044)呈负向关联。结论:我们的研究结果提示,通过调节宿主肠道微生物群进而提高肠木脂素的产生能力,可能是一种预防肥胖的潜在干预靶点。
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