Urinary Equol and Equol-Predicting Microbial Species Are Favorably Associated With
Cardiometabolic Risk Markers in Chinese Adults
尿液雌马酚及雌马酚代谢相关肠道菌群与中国成年人心脏代谢风险指标的改善相关
Author: Shaoxian Liang, Honghua Zhang, Yufeng Mo, Yamin Li, Xiaoyu Zhang, Hongjuan Cao, Shaoyu Xie, Danni Wang, Yaning Lv, Yaqin Wu, Zhuang Zhang, Wanshui Yang
Source: Journal of the American Heart Association
DOI: 10.1161/JAHA.123.034126
Abstract
Background: The association between soy isoflavones intake and cardiometabolic health remains inconclusive. We investigated the associations of urinary biomarkers of isoflavones including daidzein, glycitein, genistein, equol (a gut microbial metabolite of daidzein), and equol-predicting microbial species with cardiometabolic risk markers.
Methods and Results: In a 1-year study of 305 Chinese community-dwelling adults aged ≥18years, urinary isoflavones, fecal microbiota, blood pressure, blood glucose and lipids, and anthropometric data were measured twice, 1 year apart. Brachial ankle pulse wave velocity was also measured after 1year. A linear mixed-effects model was used to analyze repeated measurements. Logistic regression was used to calculate the adjusted odds ratio (aOR) and 95% CI for the associations for arterial stiffness. Each 1 μg/g creatinine increase in urinary equol concentrations was associated with 1.47%, 0.96%, and 3.32% decrease in triglycerides, plasma atherogenic index, and metabolic syndrome score, respectively (all P<0.05), and 0.61% increase in high-density lipoprotein cholesterol (P=0.025). Urinary equol was also associated with lower risk of arterial stiffness (aOR, 0.28 [95% CI, 0.09–0.90]; Ptrend=0.036). We identified 21 bacterial genera whose relative abundance was positively associated with urinary equol (false discovery rate-corrected P<0.05) and constructed a microbial species score to reflect the overall equol-predicting capacity. This score (per 1-point increase) was inversely associated with triglycerides (percentage difference=−1.48%), plasma atherogenic index (percentage difference=−0.85%), and the risk of arterial stiffness (aOR, 0.27 [95% CI, 0.08–0.88]; all P<0.05).
Conclusions: Our findings suggest that urinary equol and equol-predicting microbial species may improve cardiometabolic risk parameters in Chinese adults.
摘要
背景:大豆异黄酮摄入与心脏代谢健康之间的关系尚不确定。我们研究了大豆苷元、黄豆黄素、染料木黄酮和雌马酚(一种大豆苷元的肠道微生物代谢物)等大豆异黄酮尿液生物标志物及雌马酚代谢相关肠道菌属与心脏代谢风险指标之间的关联。方法与结果:在为期1年的研究中,我们收集了305名年龄≥18岁的中国社区居民1年前后两次的尿液异黄酮、粪便微生物、血压、血糖、血脂以及体格测量等数据,并在随访1年后测量了肱踝脉搏波速度。使用线性混合效应模型分析重复测量的数据。利用logistic回归计算动脉硬化患病风险关联的优势比(Odds Ratio,OR)及95%可信区间(Confidence Interval,CI)。结果发现每增加1μg/g肌酐的尿液雌马酚,甘油三酯、血浆动脉粥样硬化指数和代谢综合征评分分别降低1.47%、0.96%和3.32%(P值均<0.05),高密度脂蛋白胆固醇增加0.61%(P=0.025)。尿液雌马酚还与较低的动脉硬化风险相关[aOR,0.28(95% CI,0.09–0.90);Ptrend=0.036]。我们鉴定出21种与尿液雌马酚呈正相关的微生物菌属(经错误发现率校正后P<0.05),并构建了一个微生物菌属评分以反映个体雌马酚产生能力。该得分(每增加1分)与甘油三酯(变化百分比=−1.48%)、血浆动脉粥样硬化指数(变化百分比=−0.85%)和动脉硬化风险[aOR,0.27(95% CI,0.08–0.88);P值均<0.05]均呈负向关联。结论:我们的研究结果发现,尿液中的雌马酚及雌马酚代谢相关肠道菌群可能与中国成年人的心脏代谢风险指标改善相关。
扫一扫在手机打开当前页