高水平炎症标志物显著增加大学生抑郁症状的发生风险

Association between inflammatory markers and the change of depressive symptoms in college students

炎症标志物水平与大学生抑郁症状变化的关联

Authors：Che Wanyu , Tao Shuman , Yang Yajuan , Zou Liwei , Xie Yang , Li Tingting , Chen Yuming , Wang Meng , Mou Xingyue , Tao Fangbiao , Wu Xiaoyan

Source：Journal of Hygiene Research 

DOI: 10.19813/j.cnki.weishengyanjiu.2025.01.018

Abstract

Objectives: To analyze the associations between levels of inflammatory markers and the change of depressive symptoms in college students.

Methods: From April to May 2019, 1179 freshmen were selected by cluster random sampling in two universities in Hefei, Anhui Province and Shangrao, Jiangxi Province for baseline survey. General demographic information of college students was collected through questionnaire survey, and the depressive symptoms of college students in the past week were evaluated by the depression subscale in the Depression Anxiety Stress Scale. Two follow-up surveys were conducted six months and one year later, respectively. Blood samples were collected at baseline to measure levels of five inflammatory markers: interleukin-6 ( IL-6 ) , interleukin-1β ( IL-1β ) , tumor necrosis factor-α ( TNF-α ) , hypersensitive C-reactive protein ( hs-CRP) and interleukin-10 ( IL-10) . Multiple logistic regression model was used to analyze the association between five inflammatory markers and the change of depressive symptoms.

Results: Among the subjects included in the study, 53. 9% were from rural areas, 67. 5% were female, 6. 9% were smokers and 21. 9% were drinkers. The detection rate of depressive symptoms at baseline was 21. 1%. After 1 year follow-up, the rate of new depressive symptoms was 8. 5%. Higher levels of IL-6 (OR=2. 36, 95% CI:1. 10-5. 04) and IL-1β (OR=2. 93, 95% CI:1. 36-6. 32) at baseline were significantly positively correlated with new depressive symptoms in college students, and lower levels of IL-10 were significantly positively correlated with new depressive symptoms in college students ( OR=3. 92, 95% CI:1. 73 - 8. 86 ) .

Conclusions: High levels of IL-6, IL-1β and low levels of IL-10 at baseline were positively associated with new depressive symptoms in college students.

Keywords: interleukin-6, interleukin-1β, interleukin-10, depressive symptom, longitudinal study

摘要

目的：分析大学生炎症标志物水平与抑郁症状变化之间的关联情况。

方法：于2019年4月～5月在安徽省合肥市和江西省上饶市2所高校,采用整群随机抽样的方法选取1 179名在校大一新生进行基线调查，通过问卷调查收集大学生一般人口统计学信息，通过《抑郁—焦虑—压力自评量表》中的抑郁分量表评估大学生过去一周的抑郁症状,分别于2019年11月、2020年5～6月进行随访调查。在基线时收集研究对象的血液样本,检测白细胞介素-6( interleukin-6，IL-6) 、白细胞介素-1β（interleukin-1，IL-1β）、肿瘤坏死因子-α（tumor necrosis factor，TNF-α）、 超敏C反应蛋白（hypersensitive C-reactive protein，hs-CRP )和白细胞介素-10（interleukin-10，IL-10) 5种炎症标志物水平。采用多元Logistic 回归模型分析5种炎症标志物与抑郁症状变化的关联。

结果：调查对象中来自农村地区占53. 9％、女性占67. 5％、吸烟占6. 9％、饮酒者占21. 9％。基线时大学生抑郁症状的检出率为21. 1％经过1年随访，大学生抑郁症状新发率为8. 5％。基线较高水平的IL-6（OR＝2. 36，95% CI：1. 10 ~ 5. 04）和 IL-1β（OR＝2. 93，95% CI：1. 36 ~ 6. 32）与大学生新发抑郁症状呈显著正相关，低水平的 IL-10 与大学生新发抑郁症状呈显著正相关（OR＝3. 92，95% CI：1. 73 ~ 8. 86）。

结论：基线高水平的IL-6、IL-1β和低水平的IL-10与大学生新发抑郁症状之间呈正关联。

关键词：白细胞介素-6；白细胞介素-1β；白细胞介素-10；抑郁症状；纵向研究